Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats

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Metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.

Metformin, an antihyperglycemic agent used for treatment of type 2 diabetes mellitus, lowers blood pressure in humans and experimental animals. We recently demonstrated that short-term administration of metformin may lower blood pressure by reducing sympathetic neural outflow. The present studies were initiated to determine whether long-term administration of metformin blunts salt-induced hyper...

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ژورنال

عنوان ژورنال: American Journal of Hypertension

سال: 2001

ISSN: 0895-7061

DOI: 10.1016/s0895-7061(01)02220-8